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[Note: Alright, this seems to be spreading quickly. I didn't edit the video, my friend did but would rather not upload ponies to his work related account. I helped come up with the quote ideas and did the photoshops of the ESRB and ME2 logo (mine was Mass Equestria, he changed it to pony effect, which we is better]
Edit2: Pretty awesome that both Brandon Keener (voice of Garrus) and Keythe Farley (Thane) both posted this on their facebook pages. Sup guys.
Pony Effect 2 - Friendship is Magic
Spike as Commander Shepard
Big Macintosh as The Illusive Man
Rarity as Miranda
Celestia as Thane
Zecora is Jacob
Twilight Sparkle is Tali/Jack
Diamond Dogs & Parasprites as the Collectors
Applejack as Shepard's stunt double
And Rainbow Dash as the SSV Normandy.
My Little Pony is owned and copyrighted by Hasbro.
My Little Pony: Friendship is Magic is developed for television by Lauren Faust.
Mass Effect 2 is owned and copyrighted by Bioware/EA.
This is a parody created by fans of both licenses who are not attempting to profit from this video.